3-Cyano-2-fluoropyridine → 2-(6-Chloro-5-fluoro-pyridin-3-yloxy)-nicotinonitrile

HRID 1512258노트

반응식

HRID 1512258 반응식
F[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[Cl:10][C:11]1[N:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]=1[F:18]>>[Cl:10][C:11]1[N:16]=[CH:15][C:14]([O:17][C:2]2[N:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])=[CH:13][C:12]=1[F:18]

참가 물질

3

반응물 2

HCID 27832543-Cyano-2-fluoropyridineHCID 404247372-Chloro-3-fluoro-5-hydroxypyridine

생성물 1

HCID 860822952-(6-Chloro-5-fluoro-pyridin-3-yloxy)-nicotinonitrile

실험 절차

2-Fluoro-nicotinonitrile was reacted with 6-chloro-5-fluoro-pyridin-3-ol according to the method of Example 85A to provide the title compound. MS (DCI/NH3) m/z 250 (M)+, 252 (M+2)+.

출처 및 근거

ORD 기록
ord-5f8f234f4bb9474fb92a95a2843dfb45
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217067B2

반응 노트

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