HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloronicotinonitrile → 2-(2,4,6-Trifluorophenyl)nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloronicotinonitrile | HCID 81079 | — |
| Reactant | 2,4,6-Trifluorophenylboronic Acid | HCID 2779329 | — |
| Product | 2-(2,4,6-Trifluorophenyl)nicotinonitrile | HCID 68583335 | 82% |
Reaction Steps
Prepared in 82% yield from 2-chloronicotinonitrile and 2,4,6-trifluorophenylboronic acid according to the procedure described for Example 153A. MS (ESI+) m/z 235.0 (M+H)+; 1H NMR (CDCl3) δ 6.83-6.88 m, 2H), 7.51 (dd, J=8.0, 4.9 Hz, 1H), 8.12 (dd, J=8.1, 1.7 Hz, 1H), 8.94 (dd, J=5.1, 1.7 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217067B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-963b722d117046d0bea53ba8f899f826 |
| Source note | uspto-grants-2012_07 |