HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 2-(1-Pyrrolidinyl)-6-(trifluoromethyl)-3-pyridinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-Chloro-6-(trifluoromethyl)nicotinonitrile | HCID 2778413 | — |
| Product | 2-(1-Pyrrolidinyl)-6-(trifluoromethyl)-3-pyridinecarbonitrile | HCID 10263709 | 67% |
Reaction Steps
Prepared in 67% yield from 2-chloro-6-trifluoromethyl-nicotinonitrile and pyrrolidine according to the procedure described for Example 178A. MS (ESI+) m/z 242.9 (M+H)+; 1H NMR (DMSO-d6) δ 1.92-1.97 (m, 4H), 3.67-3.72 (m, 4H), 7.07 (d, J=7.8 Hz, 1H), 8.22 (d, J=7.8 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217067B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-7a8ffa04378f4e22a8b80a0926a1a37f |
| Source note | uspto-grants-2012_07 |