Lithium borohydride → [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

Participants

Role	Name	HCID	Charge
Reactant	Lithium borohydride	HCID 4148881	—
Reactant	Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate	HCID 56604575	—
Solvent	Ethanol	HCID 702	—
Product	[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol	HCID 58218538	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid methyl ester (5 g, 16.8 mmol) and lithium borohydride (1.85 g, 84.1 mmol) were combined in EtOH and stirred at 60° C. After aqueous workup, the crude material was purified by silica gel chromatography to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08217066B2
Source dataset	uspto-grants-2012_07
ORD ID	ord-94eefd45ccdb420d836a1638f1c257e4
Source note	uspto-grants-2012_07