反应详情

5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde (0.150 g, 0.56 mmol) and N-methyl-phenethylamine (0.10 mL, 0.67 mmol) were combined in MeOH and stirred at room temperature overnight. Once no starting material was seen by analytical LCMS, sodium borohydride (0.064 g, 1.69 mmol) was added and the reaction was stirred at room temperature for 1 hour. H2O was added and the mixture was extracted with EtOAc. The combined organic layers were dried and concentrated, and the residue was purified by silica gel chromatography to give the title compound.

1. additionwas added
2. stirringthe reaction was stirred at room temperature for 1 hour
3. extractionthe mixture was extracted with EtOAc
4. customThe combined organic layers were dried
5. concentrationconcentrated
6. customthe residue was purified by silica gel chromatography