Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1512592Generated: November 3, 2026

1-(Bromomethyl)-3-chlorobenzene → 1-(4'-{4-[2-(3-Chloro-benzyloxy)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

https://huagongshe.com/reaction/1512592

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-3-chlorobenzeneHCID 69838—
Reactant1-{4'-[4-(2-Hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl esterHCID 66577266—
Product1-(4'-{4-[2-(3-Chloro-benzyloxy)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acidHCID 51352395—

Reaction Steps

Prepared according to the procedure described in Example 14, Step 4, using 1-{4′-[4-(2-Hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester and 1-bromomethyl-3-chloro-benzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217066B2
Source datasetuspto-grants-2012_07
ORD IDord-71641b2eb0414cc38b4127b39ceaefff
Source noteuspto-grants-2012_07