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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1512593Generated: November 2, 2026

1-(Bromomethyl)-4-chlorobenzene → 1-(4'-{4-[2-(4-Chloro-benzyloxy)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

https://huagongshe.com/reaction/1512593

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-chlorobenzeneHCID 69329—
Reactant1-{4'-[4-(2-Hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl esterHCID 66577266—
Product1-(4'-{4-[2-(4-Chloro-benzyloxy)-ethyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acidHCID 51352398—

Reaction Steps

Prepared according to the procedure described in Example 14, Step 4, using 1-{4′-[4-(2-hydroxy-ethyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester and 1-bromomethyl-4-chloro-benzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217066B2
Source datasetuspto-grants-2012_07
ORD IDord-09d47c25c880497cac1a010467de9bfc
Source noteuspto-grants-2012_07