関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | 2-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanol | HCID 66577296 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Methanesulfonic acid 2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]ethyl ester | HCID 86652398 | — |
反応手順
To a solution of 2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-ethanol (0.100 g, 0.35 mmol) and triethylamine (0.10 mL, 0.71 mmol) in THF at 0° C. was added methanesulfonyl chloride (0.05 mL, 0.62 mmol) and the reaction stirred at 0° C. for 1 hour. The mixture was diluted with H2O and extracted with EtOAc, and the combined organic layers were washed with H2O, saturated aqueous NaHCO3, and brine. Dried over MgSO4, filtered, and concentrated to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08217066B2 |
|---|
| 出典データセット | uspto-grants-2012_07 |
|---|
| ORD ID | ord-bd286ca53d414897ab6998f1fb81bc2b |
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| 出典メモ | uspto-grants-2012_07 |
|---|
