Sodium borohydride → HCID 51352480, compound

HRID 1512600Notes

Reaction equation

HRID 1512600 reaction equation
[CH3:1][C:2]1[C:6]([CH2:7][C:8](=[O:17])[CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:5]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]4([C:33]([OH:35])=[O:34])[CH2:32][CH2:31]4)=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)[O:4][N:3]=1.[BH4-].[Na+]>CO>[OH:17][CH:8]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:7][C:6]1[C:2]([CH3:1])=[N:3][O:4][C:5]=1[C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3([C:33]([OH:35])=[O:34])[CH2:32][CH2:31]3)=[CH:26][CH:25]=2)=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 66577306HCID 66577306, compound

Product 1

HCID 51352480HCID 51352480, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-{4′-[3-Methyl-4-(2-oxo-4-phenyl-butyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (0.015 g, 0.03 mmol) in MeOH was treated with sodium borohydride (0.001 g, 0.03 mmol) and stirred at room temperature for 5 minutes. Aqueous workup provided the title compound.

Sources & evidence

ORD record
ord-5e4827d078874aa983f532f29d8aada4
Source dataset
uspto-grants-2012_07
Patent number
US08217066B2

Reaction notes

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