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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1512640Generated: November 1, 2026

Sodium Iodide → HCID 66577474, compound

https://huagongshe.com/reaction/1512640

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium IodideHCID 5238—
Reactant3-bromo-3,3-difluoroprop-1-eneHCID 555085—
ReactantIndiumHCID 5359967—
Reactant5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehydeHCID 82133792—
SolventDimethylformamideHCID 6228—
ProductHCID 66577474HCID 66577474—

Reaction Steps

5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde (0.511 g, 1.92 mmol), 3-bromo-3,3-difluoro-propene (0.4977 g, 3.07 mmol), indium (0.357 g, 3.07 mmol) and sodium iodide (0.0142 g, 0.096 mmol) were combined in DMF (5 mL) and stirred at room temperature overnight. The reaction mixture was submitted to standard aqueous workup to afford the title compound, which was taken to the next step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217066B2
Source datasetuspto-grants-2012_07
ORD IDord-e6a8ad9c6ca8477a9e786cabf7114cf0
Source noteuspto-grants-2012_07