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4-[3-(Trifluoromethyl)phenyl]butan-2-one → [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-methyl-3-(3-trifluoromethyl-phenyl)-propyl]-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-[3-(Trifluoromethyl)phenyl]butan-2-one | HCID 13339059 | — |
| 反応物 | 5-(4-Bromophenyl)-3-methylisoxazol-4-amine | HCID 58218537 | — |
| 生成物 | [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-methyl-3-(3-trifluoromethyl-phenyl)-propyl]-amine | HCID 66577310 | — |
反応手順
: Prepared according to the procedure described in Example 8, Step 1, using 5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylamine and 4-(3-trifluoromethyl-phenyl)-butan-2-one. After silica gel chromatography the crude material was purified via preparatory chiral HPLC (Chiralcel-AD column, 2% EtOH in hexanes, 35 minutes) to afford two separate enantiomers. The first enantiomer eluted from the column is the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08217066B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-4ebce62d078f4852a59f651a49dbd963 |
| 出典メモ | uspto-grants-2012_07 |