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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1512673Generated: November 2, 2026

4-Fluoroiodobenzene → (E)-1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-4-(4-fluoro-phenyl)-but-3-en-1-ol

https://huagongshe.com/reaction/1512673

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-FluoroiodobenzeneHCID 9605—
ReactantHCID 66577474HCID 66577474—
Product(E)-1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-4-(4-fluoro-phenyl)-but-3-en-1-olHCID 66582165—

Reaction Steps

Prepared according to the procedure described in Example 39, Step 1, using 1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-but-3-en-1-ol and 1-fluoro-4-iodo-benzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217066B2
Source datasetuspto-grants-2012_07
ORD IDord-612edab009e64c2d94ccfdbb2fee1521
Source noteuspto-grants-2012_07