3-(Trifluoromethyl)benzyl mercaptan → 1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2-(3-trifluoromethyl-benzylsulfanyl)-ethanol

HRID 1512675Notes

Reaction equation

HRID 1512675 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]2[CH2:16][O:15]2)=[CH:4][CH:3]=1.[F:17][C:18]([F:28])([F:27])[C:19]1[CH:20]=[C:21]([CH2:25][SH:26])[CH:22]=[CH:23][CH:24]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]([OH:15])[CH2:16][S:26][CH2:25][C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([C:18]([F:17])([F:27])[F:28])[CH:20]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1412363-(Trifluoromethyl)benzyl mercaptanHCID 866524045-(4-Bromo-phenyl)-3-methyl-4-oxiranyl-isoxazole

Product 1

HCID 665772881-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2-(3-trifluoromethyl-benzylsulfanyl)-ethanol

Procedure

Prepared according to the procedure described in Example 58, Step 1, using 5-(4-bromo-phenyl)-3-methyl-4-oxiranyl-isoxazole and (3-trifluoromethyl-phenyl)-methanethiol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b01785eb26254970b388ff956d8eba29
Source dataset
uspto-grants-2012_07
Patent number
US08217066B2

Reaction notes

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