Acetic acid 1-benzyl-2-oxo-propyl ester → Acetic acid 1-benzyl-2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylamino]-propyl ester

HRID 1512680Notes

Reaction equation

HRID 1512680 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[NH2:14])=[CH:4][CH:3]=1.[CH2:15]([CH:22]([O:26][C:27](=[O:29])[CH3:28])[C:23](=O)[CH3:24])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([CH:22]([O:26][C:27](=[O:29])[CH3:28])[CH:23]([NH:14][C:9]1[C:10]([CH3:13])=[N:11][O:12][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1)[CH3:24])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 12384128Acetic acid 1-benzyl-2-oxo-propyl esterHCID 582185375-(4-Bromophenyl)-3-methylisoxazol-4-amine

Product 1

HCID 66577318Acetic acid 1-benzyl-2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylamino]-propyl ester

Procedure

Prepared according to the procedure described in Example 8, Step 1, using 5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylamine and acetic acid 1-benzyl-2-oxo-propyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-554570b190364e71bb8580d634020d1b
Source dataset
uspto-grants-2012_07
Patent number
US08217066B2

Reaction notes

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