N-{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarbonyl}-methanesulfonamide → HCID 66577262, compound

HRID 1512696Notes

Reaction equation

HRID 1512696 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]([OH:26])[C:15]([F:25])([F:24])/[CH:16]=[CH:17]/[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:4][CH:3]=1.CC1(C)C(C)(C)OB([C:35]2[CH:40]=[CH:39][C:38]([C:41]3([C:44]([NH:46][S:47]([CH3:50])(=[O:49])=[O:48])=[O:45])[CH2:43][CH2:42]3)=[CH:37][CH:36]=2)O1>>[F:24][C:15]([F:25])(/[CH:16]=[CH:17]/[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH:14]([C:9]1[C:10]([CH3:13])=[N:11][O:12][C:8]=1[C:5]1[CH:6]=[CH:7][C:2]([C:35]2[CH:36]=[CH:37][C:38]([C:41]3([C:44]([NH:46][S:47]([CH3:50])(=[O:49])=[O:48])=[O:45])[CH2:43][CH2:42]3)=[CH:39][CH:40]=2)=[CH:3][CH:4]=1)[OH:26]

Participants

3

Reactant 2

HCID 66577823N-{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarbonyl}-methanesulfonamideHCID 66582181HCID 66582181, compound

Product 1

HCID 66577262HCID 66577262, compound

Procedure

Prepared according to the procedure described in Example 110, Step 3, using (E)-1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-4-phenyl-but-3-en-1-ol and N-{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarbonyl}-methanesulfonamide.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ee92af433ea8470aa2f59e0eafa5c9bc
Source dataset
uspto-grants-2012_07
Patent number
US08217066B2

Reaction notes

Loading…