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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1512699Generated: November 4, 2026

Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylate → 1-(4'-{4-[1-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid ethyl ester

https://huagongshe.com/reaction/1512699

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylateHCID 53217182—
Reactant5-(4-Bromo-phenyl)-4-[1-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-3-methyl-isoxazoleHCID 66579934—
Product1-(4'-{4-[1-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid ethyl esterHCID 66580085—

Reaction Steps

Prepared according to the procedure described in Example 2, using 5-(4-bromo-phenyl)-4-[1-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-3-methyl-isoxazole and 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid ethyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217066B2
Source datasetuspto-grants-2012_07
ORD IDord-a446ab5b0e4d4b88ae7e2b2b04bb05f1
Source noteuspto-grants-2012_07