反应详情

MnO2 (1.76 g) was added to a solution of 2-(hydroxymethyl)-1H-indole-5-carbonitrile (D24) (290 mg) in dichloromethane (100 mL) at RT. The reaction mixture was stirred at RT for 1 hour. The solid was filtered off and washed with dichloromethane. The filtrate was concentrated to afford 2-formyl-1H-indole-5-carbonitrile (D28) (230 mg) as a white solid. MS (ES): C10H6N2O requires 170; found 169.1 (M−H+).

1. filtrationThe solid was filtered off
2. washwashed with dichloromethane
3. concentrationThe filtrate was concentrated