HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl (2E)-3-(5-cyano-1H-indol-2-yl)-2-propenoate → ethyl 3-(5-cyano-1H-indol-2-yl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl (2E)-3-(5-cyano-1H-indol-2-yl)-2-propenoate | HCID 67025185 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | ethyl 3-(5-cyano-1H-indol-2-yl)propanoate | HCID 67025284 | 99.2% |
Reaction Steps
Ethyl (2E)-3-(5-cyano-1H-indol-2-yl)-2-propenoate (D29) (200 mg) in methanol (40 mL) and EtOAc (20 mL) was hydrogenated using the H-cube (full mode) with a large 10% Pd—C catcart (flow rate: 2.5 mL/min). The solvent was evaporated to afford ethyl 3-(5-cyano-1H-indol-2-yl)propanoate (D30) (200 mg) as a white solid. MS (ES): C14H14N2O2 requires 242; found 243.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217028B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-6a9ddd9792ca4676825528d1ad0fc610 |
| Source note | uspto-grants-2012_07 |