Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → ethyl (2E)-3-(7-cyano-4-fluoro-1H-indol-3-yl)-2-propenoate

Participants

Reaction Steps

To a mixture of 4-fluoro-3-formyl-1H-indole-7-carbonitrile (D42) (9.0 g) in CH3CN (120 mL) was added ethyl (triphenylphosphoranyliden)acetate (25.0 g). The reaction was heated at reflux overnight. After the mixture was filtered, the filtrate was concentrated and purified by preparative TLC to afford ethyl (2E)-3-(7-cyano-4-fluoro-1H-indol-3-yl)-2-propenoate (D43) (9.2 g) as a yellow solid.

Provenance & Evidence