Sodium borohydride → HCID 59146044, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-[7-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indol-3-yl]propanal (D92) (300 mg) was added NaBH4 (138 mg). The reaction mixture was stirred at 20° C. overnight. The reaction mixture was evaporated and the residue was partitioned between DCM (50 mL) and water (25 mL). The organic phase was washed with water and brine, dried over sodium sulphate and evaporated in vacuo to afford the product 3-[7-(5-{3-chloro-4-[(1-methyl ethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indol-3-yl]-1-propanol as a white solid (D99) (280 mg). MS (ES): C22H22ClN3O3 requires 411; found 412.2 (M+H+).

Provenance & Evidence