1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → ethyl 3-[6-(5-{5-methyl-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-1H-indol-3-yl]propanoate

Participants

Reaction Steps

EDCI (590 mg) and HOBT (507 mg) were added to a solution of 5-methyl-6-[(1-methylethyl)oxy]-3-pyridinecarboxylic acid (300 mg) in THF (5 mL) at RT. The resulting solution was stirred for 30 mins. Ethyl 3-{6-[(Z)-(hydroxyamino)(imino)methyl]-1H-indol-3-yl}propanoate (D107) (845 mg) in THF (5 mL) was added and the reaction mixture was stirred at RT for 2 hours. TBAF (1.6 g) was then added. The reaction vessel was sealed and heated in Biotage Initiator using initial normal to 120° C. for 2 hours. After cooling, the reaction was quenched with water, and extracted with EtOAc for 3 times. The combined organic solution was washed with brine, dried over anhydrous sodium sulfate. The dried solution was concentrated. The residue was purified by column chromatography (20% EtOAc in hexane) to afford ethyl 3-[6-(5-{5-methyl-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-1H-indol-3-yl]propanoate (D111) (310 mg) as a pale yellow solid. MS (ES): C24H26N4O4 requires 434; found 435.2 (M+H+).

Provenance & Evidence