HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → Ethyl (2E)-3-(7-cyano-6-fluoro-1H-indol-3-yl)-2-propenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| Reactant | 6-fluoro-3-formyl-1H-indole-7-carbonitrile | HCID 59146048 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl (2E)-3-(7-cyano-6-fluoro-1H-indol-3-yl)-2-propenoate | HCID 59146028 | 58.3% |
Reaction Steps
To a mixture of 6-fluoro-3-formyl-1H-indole-7-carbonitrile (D142) (3 g) in CH3CN (30 mL) was added ethyl (triphenylphosphoranylidene)acetate (11.1 g). The reaction was heated to reflux overnight. After the mixture was filtered, the filtrate was concentrated and purified by column chromatography to afford ethyl (2E)-3-(7-cyano-6-fluoro-1H-indol-3-yl)-2-propenoate (D143) (2.4 g) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217028B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-d2fce5705d54401a834434af9c76a324 |
| Source note | uspto-grants-2012_07 |