Sodium Hydroxide → Sodium 3-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl]propanoate

Participants

Reaction Steps

Aqueous NaOH solution (2 N, 2 mL) was added to a solution of ethyl 3-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl]propanoate (D33) (90 mg) in ethanol (20 mL) at RT. The resulting solution was stirred for 30 min. Ethanol was evaporated. Saturated aqueous sodium chloride solution (10 mL) was added. The mixture was extracted with EtOAc (2×50 mL). The organic fractions were combined. The combined solution was dried over anhydrous magnesium sulfate. The dried solution was concentrated. The residue was triturated with ether to afford sodium 3-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl]propanoate (E9) (80 mg) as a white solid. δH (CD3OD, 400 MHz): 1.44 (6H, d), 2.62 (2H, t), 3.08 (2H, t), 4.87 (1H, m), 6.33 (1H, d), 7.33 (1H, d), 7.41 (1H, d), 7.80 (1H, dd), 8.14 (1H, dd), 8.24 (2H, dd). MS (ES): C22H19ClN3O4Na requires 447; found 425.9 (M—Na++2H+).

Provenance & Evidence