Hydrochloric Acid → HCID 44548737, compound

Participants

Reaction Steps

To a stirred solution of N-{[7-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-methyl-1H-indol-3-yl]methyl}-L-alaninate (D81) (160 mg) in THF (2 mL) was added NaOH (2 M, 2 mL). The reaction was stirred at room temperature overnight. The reaction mixture was acidified with HCl (2 M) to pH 6-7. The resulting solid was separated and suspended in methanol (2 mL) with stirring, HCl (2 M) was added until the solid dissolved completely. The solution was freeze dried to afford N-{[7-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-methyl-1H-indol-3-yl]methyl}-L-alanine (E60) (130 mg, HCl salt). δH (DMSO-d6, 400 MHz): 1.35 (6H, d), 1.50 (3H, d), 3.70 (3H, s), 3.92 (1H, q), 4.36 (2H, s), 4.88 (1H, m), 7.28 (1H, t), 7.45 (1H, d), 7.51 (1H, d), 7.62 (1H, s), 8.04 (1H, d), 8.13 (1H, d), 8.20 (1H, d). MS (ES): C24H26ClN4O4 requires 468; found 380.2 (M—C3H6NO2+).

Provenance & Evidence