Hydrochloric Acid → 3-(5-{5-[6-[(1-methylethyl)oxy]-5-(methyloxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl}-1H-indol-2-yl)propanoic acid

Participants

Reaction Steps

Sodium hydroxide (3 mg) was added to a solution of ethyl 3-(5-{5-[6-[(1-methylethyl)oxy]-5-(methyloxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl}-1H-indol-2-yl)propanoate (D118) (35 mg) in THF (5 mL), isopropanol (5 mL) and water (2.5 mL). The reaction mixture was stirred at room temperature overnight. The mixture was neutralized with 2 M HCl till pH ˜6.0. The crude product was purified by Mass Directed Auto Prep to afford 3-(5-{5-[6-[(1-methylethyl)oxy]-5-(methyloxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl}-1H-indol-2-yl)propanoic acid (E93) (5 mg). δH (DMSO-d6, 400 MHz): 1.35 (6H, d), 2.70 (2H, t), 2.99 (2H, t), 3.94 (3H, s), 5.42 (1H, m), 6.34 (1H, s), 7.45 (1H, d), 7.76 (1H, dd), 7.83 (1H, d), 8.23 (1H, s), 8.54 (1H, d), 11.34 (1H, s), 12.26 (1H, s); MS (ES): C22H22N4O5 requires 422; found 423.2 (M+H+).

Provenance & Evidence