反应详情

温度

90 °C

To a solution of ethyl 3-[7-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-fluoro-1H-indol-3-yl]propanoate (D146) (320 mg) in isopropanol (7 mL) and water (7.00 mL) was added NaOH (6.78 mL, 0.5 M aqueous solution) at room temperature. The reaction suspension was stirred at 90° C. for 2 hours, and the solution turned clear. Isopropanol was removed in vacuo and water (8 mL) was added to the residue. The aqueous solution was acidified to pH=1 and extracted with ethyl acetate (3×10 mL). The combined organic phases were dried over sodium sulphate. The organic solution was concentrated and the residue was purified by MDAP to afford 3-[7-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-fluoro-1H-indol-3-yl]propanoic acid (E103) (140 mg) as a white solid. δH (DMSO-d6, 400 MHz): 1.31 (6H, d), 2.56 (2H, t), 2.92 (2H, t), 4.85 (1H, m), 7.03 (1H, m), 7.22 (1H, s), 7.39 (1H, d), 7.74 (1H, m), 8.21 (1H, dd), 8.47 (1H, d), 11.01 (1H, s), 12.07 (1H, s). MS (ES): C22H19ClFN3O4 requires 443; found 444.2 (M+H+).

1. customIsopropanol was removed in vacuo and water (8 mL)
2. additionwas added to the residue
3. extractionextracted with ethyl acetate (3×10 mL)
4. dry with materialThe combined organic phases were dried over sodium sulphate
5. concentrationThe organic solution was concentrated
6. customthe residue was purified by MDAP