1H-Benzimidazole, 2-(chloromethyl)-1-ethyl- → tert-butyl (3RS,4RS,5SR)-4-(4-chloro-phenyl)-3-(1-ethyl-1H-benzimidazol-2-ylmethoxy)-5-propyl-piperidine-1-carboxylate

HRID 151301Notes

Reaction equation

HRID 151301 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([OH:24])[CH2:10][N:11]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:12][CH:13]2[CH2:14][CH2:15][CH3:16])[cH:6][cH:7]1.[Cl:25][CH2:26][c:27]1[n:28][c:29]2[c:30]([n:31]1[CH2:32][CH3:33])[cH:34][cH:35][cH:36][cH:37]2>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([O:24][CH2:26][c:27]3[n:28][c:29]4[c:30]([n:31]3[CH2:32][CH3:33])[cH:34][cH:35][cH:36][cH:37]4)[CH2:10][N:11]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:12][CH:13]2[CH2:14][CH2:15][CH3:16])[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 124084321H-Benzimidazole, 2-(chloromethyl)-1-ethyl-HCID 86604427tert-butyl (3RS,4RS,5SR)-4-(4-chloro-phenyl)-3-hydroxy-5-propyl-piperidine-1-carboxylate

Product 1

HCID 86604429tert-butyl (3RS,4RS,5SR)-4-(4-chloro-phenyl)-3-(1-ethyl-1H-benzimidazol-2-ylmethoxy)-5-propyl-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-6fe7ed654a5943e3a377de6657e1d083
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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