Hydrochloric Acid → HCID 178426676, compound

Participants

Reaction Steps

To a solution of 3-[2-chloro-5-(2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl-sulfonyl)phenyl]-5-cyano-7-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (0.13 g) in ethanol (4 mL) were added hydroxylamine hydrochloride (91 mg) and potassium carbonate (0.2 g), and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into 1 mol/L hydrochloric acid, and the resulting mixture was extracted with ethyl acetate. The extract was washed with water and brine, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residual solids were suspended in a mixed solvent (n-hexane/ethyl acetate=4/1), and collected by filtration. The collected solids were dried under reduced pressure to give the title compound (0.1 g).

Provenance & Evidence