Hydrochloric Acid → HCID 68516930, compound

Participants

Reaction Steps

To a solution of 2-(tert-butoxycarbonylaminomethyl)-9-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenyl]-6-methoxy-7,9-dihydro-8H-purin-8-one (36 mg) in tetrahydrofuran (1 mL) was added hydrochloric acid (4 mol/L ethyl acetate solution, 2 mL) under ice-cooling, and the mixture was stirred at the same temperature for 1 hour, and then stirred at room temperature for 3 hours. To the reaction mixture was added diethyl ether, and the insoluble material was collected by filtration. The collected material was washed with diethyl ether, and dried under reduced pressure to give the title compound (14 mg).

Provenance & Evidence