Tetrabutylammonium Fluoride → HCID 59309905, compound

Participants

Reaction Steps

To a solution of 2-{4-[5-(tert-butyldimethylsilyloxy)methyl-7-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one-3-yl]-5-chloro-2-(2-fluoro-6-methoxybenzyloxy)phenoxy}-N,N-dimethylacetamide (40 mg) in tetrahydrofuran (0.6 mL) was added tetra(n-butyl)ammonium fluoride (1 mol/L tetrahydrofuran solution, 1.2 mL), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was diluted with ethyl acetate, and the mixture was washed with 1 mol/L hydrochloric acid, water and brine successively, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residual solids were suspended in a mixed solvent (n-hexane/ethyl acetate=2/1), and collected by filtration. The collected solids were dried under reduced pressure to give the title compound (16 mg).

Provenance & Evidence