HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-(2,6-dichlorophenyl)-3H-benzimidazole-5-carbonyl chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2-(2,6-Dichloro-phenyl)-3H-benzoimidazole-5-carboxylic acid | HCID 43349292 | — |
| Solvent | Thionyl Chloride | HCID 24386 | — |
| Product | 2-(2,6-dichlorophenyl)-3H-benzimidazole-5-carbonyl chloride hydrochloride | HCID 86632817 | — |
Reaction Steps
A mixture of 2-(2,6-dichlorophenyl)-3H-benzoimidazole-5-carboxylic acid (5 g) in thionyl chloride (10 mL) containing a catalytic quantity of DMF was stirred at RT for 18 h. Methylene chloride was added and the resulting solid was filtered, washed with methylene chloride and dried under reduced pressure to give the title compound as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217065B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-78761b67b12c4165bc29b54f448b2fd3 |
| Source note | uspto-grants-2012_07 |