反应详情

A mixture of 3-(4-formyl-3,5-dimethylphenyl)-acrylic acid methyl ester (900 mg, 4.1 mmol) and 10% Pd/C (90 mg) in CH2Cl2 (20 mL) was hydrogenated at one atm overnight. The catalyst was filtered through Celite and washed with CH2Cl2. The solvent was removed under reduced pressure and the residue was purified by flash chromatography (heptane/EtOAc=5:1) to give the title compound. MS: m/z 221 (M+1).

1. customwas hydrogenated at one atm overnight
2. filtrationThe catalyst was filtered through Celite
3. washwashed with CH2Cl2
4. customThe solvent was removed under reduced pressure
5. customthe residue was purified by flash chromatography (heptane/EtOAc=5:1)