Dimethylformamide → HCID 178500174, compound

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	Potassium hydroxy sulfite	HCID 23707502	—
Reactant	3-(4-{6-[5-(3-Chlorophenylamino)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid	HCID 25210591	—
Reactant	Methyl 3-(4-formyl-3,5-dimethylphenyl)-2,2-dimethylpropanoate	HCID 86632822	—
Solvent	Water	HCID 962	—
Product	HCID 178500174	HCID 178500174	—

Reaction Steps

Oxone (420 mg, 0.683 mmol) was added to a mixture of 3-(4-formyl-3,5-dimethyl-phenyl)-2,2-dimethyl-propionic acid methyl ester (250 mg, 1.00 mmol) and 4-[5-(4-Methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-benzene-1,2-diamine (prepared as described in Example 1-59, 300 mg, 1.06 mmol) in DMF (8 mL) and water (0.8 mL), and the mixture was stirred at room temperature for 18 h. The mixture was partitioned between EtOAc and water. The EtOAc extract was washed with brine, dried over Na2SO4, concentrated and chromatographed to give the title compound. m/z 511.3 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08217065B2
Source dataset	uspto-grants-2012_07
ORD ID	ord-08e483538d34419aa193382d6b9a763a
Source note	uspto-grants-2012_07