Water → Oxymorphone

Participants

Reaction Steps

The wet cake was charged to a flask. Water (8×1 g per g of oripavine) was charged. Agitation was turned on and nitrogen sweep was initiated. c-HCl (0.3 mL per g of oripavine) was added to form a solution (pH=about 4 to 5). A charcoal treatment and filtration was conducted when the color was dark. c-NH4OH (˜1 mL per g of oripavine) was added to adjust pH=about 9 to 10 to form a precipitate. The mixture was stirred at room temperature for 1 hour, then was filtered and washed with water (5×1 mL per g of oripavine). The resulting solid was dried under flowing air at room temperature or 1 hour to give a solid. The solid was further dried under house vacuum at 75° C. for 16 hours to give the product as a tan solid. The weight of solid should range from 0.8 g to 1.0 g per g of oripavine with peak area >95%, wt/wt 90 to 95% and water content 3 to 5%.

Provenance & Evidence