Dimethylformamide → HCID 59496105, compound

Participants

Reaction Steps

To a solution of 6-phenyl-4-(phenylcarbonyl)-1,2,4-triazine-3,5(2H,4H)-dione (84 mg, 0.286 mmol) in N,N-Dimethylformamide (DMF) (2 ml) under an argon atmosphere, triethylamine (0.050 ml, 0.359 mmol) was added and the mixture stirred at r.t. for 5 min., then acroleyn (0.020 ml, 0.299 mmol) was added and the mixture stirred overnight. Reaction was quenched by sat. NH4Cl (4 mL) and aq. layer extracted by Et2O (2×10 mL). Combined organic layers were washed by iced water, dried upon sodium sulphate and concentrated under reduced pressure to obtain 77 mg of title (77% yield).

Provenance & Evidence