Hydrochloric Acid → HCID 68433624, compound

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Reaction Steps

6-(2-methyl-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione (E5, 41.5 mg, 0.088 mmol) was dissolved in DCM and treated with 2.2 eq of HCl 1.25N in MeOH to form 6-(2-methyl-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione dihydrochloride salt (E6, 43.1 mg, 0.079 mmol).

Provenance & Evidence