HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(2-Fluoro-3-pyridinyl)-2-(3-{(1s,5r)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2h,4h)-dione dihydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 6-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione | HCID 59496089 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-(2-Fluoro-3-pyridinyl)-2-(3-{(1s,5r)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2h,4h)-dione dihydrochloride salt | HCID 86645645 | — |
Reaction Steps
6-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione (E9, 46 mg, was dissolved in 2 mL of DCM and treated with HCl 1.25M in MeOH (2.2 eq) to form 6-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione dihydrochloride salt (E10, 45 mg, 0.082 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217168B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-3dbe23efd23846c483083b3bb4e35fd4 |
| Source note | uspto-grants-2012_07 |