4-Amino-1-methylpiperidine → HCID 44512570, compound

HRID 1513445Notes

Reaction equation

C[C:2]1[CH:10]=[C:9]([NH:11][C:12](=[O:36])[NH:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:25]=[C:24]([O:26][CH:27]([CH3:29])[CH3:28])[N:23]=[C:22]([N:30]4[CH2:35][CH2:34][O:33][CH2:32][CH2:31]4)[N:21]=3)=[CH:16][CH:15]=2)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:37][CH:38]1[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]1>>[CH:27]([O:26][C:24]1[N:23]=[C:22]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[N:21]=[C:20]([C:17]2[CH:18]=[CH:19][C:14]([NH:13][C:12]([NH:11][C:9]3[CH:10]=[CH:2][C:3]([C:4]([NH:37][CH:38]4[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]4)=[O:6])=[CH:7][CH:8]=3)=[O:36])=[CH:15][CH:16]=2)[N:25]=1)([CH3:28])[CH3:29]

Participants

Reactant 2

HCID 27375314-Amino-1-methylpiperidine

HCID 67021897HCID 67021897, compound

Product 1

HCID 44512570HCID 44512570, compoundYield 27%

Procedure

Starting from methyl 4-({[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzoic acid (200 mg, 0.42 mmol) and 4-amino-1-methylpiperidine following the procedure as outlined in Experimental 71, 65 mg (27% Yield) of the titled compound was isolated as white solid. MS (ESI) m/z 574.68.

Sources & evidence

ORD record: ord-a6d3b300840848bd8cf11d4f7f191b1a
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08217036B2

Reaction notes

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