4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → 1-(4-(4-(4-Aminophenyl)-6-(3,5-dimethyl morpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea

HRID 1513484Notes

Reaction equation

HRID 1513484 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH:13]([CH3:14])[CH2:12][O:11][CH2:10][CH:9]2[CH3:15])[N:5]=[C:4]([C:16]2[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:25][CH3:26])=[O:24])=[CH:18][CH:17]=2)[N:3]=1.CC1(C)C(C)(C)OB([C:35]2[CH:41]=[CH:40][C:38]([NH2:39])=[CH:37][CH:36]=2)O1>>[NH2:39][C:38]1[CH:40]=[CH:41][C:35]([C:2]2[N:7]=[C:6]([N:8]3[CH:13]([CH3:14])[CH2:12][O:11][CH2:10][CH:9]3[CH3:15])[N:5]=[C:4]([C:16]3[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:25][CH3:26])=[O:24])=[CH:18][CH:17]=3)[N:3]=2)=[CH:36][CH:37]=1

Participants

3

Reactant 2

HCID 27346204-(Tetramethyl-1,3,2-dioxaborolan-2-yl)anilineHCID 866365241-(4-(4-Chloro-6-(3,5-dimethylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea

Product 1

HCID 674380181-(4-(4-(4-Aminophenyl)-6-(3,5-dimethyl morpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylureaYield 86%

Procedure

The title compound was prepared by following the procedure of example 462 step 4 using 1-(4-(4-chloro-6-(3,5-dimethylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline. Yield 2 g, 86% yield.

Sources & evidence

ORD record
ord-2125fb5a1a9242528154943f280ec4a2
Source dataset
uspto-grants-2012_07
Patent number
US08217036B2

Reaction notes

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