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2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine → 1-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine | HCID 224967 | — |
| 反応物 | 3-Methyl-1-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea | HCID 17750273 | — |
| 生成物 | 1-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea | HCID 45379222 | 11% |
反応手順
The title compound was prepared by following the procedure of example 473 step 2 using 4,4′-(6-chloro-1,3,5-triazine-2,4-diyl)dimorpholine and 1-Methyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea. Yield 13 mg, 11% yield; HPLC: Rt=1.98 min; MS 400 [M+H].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08217036B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-8c3e40fa492042d38f161f6b86195c90 |
| 出典メモ | uspto-grants-2012_07 |