Chloroform → 913258-22-7

HRID 1513514Notes

Reaction equation

HRID 1513514 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH3:7][CH:8]([OH:10])[CH3:9].[CH:11](Cl)(Cl)Cl>>[CH2:7]([C@H:8]1[CH2:9][O:10]1)[CH2:11][C:3]1[CH:2]=[CH:1][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 6212ChloroformHCID 21585144Isopropanol hexane

Product 1

HCID 12003885913258-22-7Yield 74%

Procedure

Colorless oily substance, 74% yield, 97% ee (CHIRALPAK IC, hexane/iPrOH 99.9:0.1); [α]D22 −16.3° (c=0.38, CHCl3)): δ7.32-7.28 (m, 2H), 7.22-7.18 (m, 3H), 2.98-2.93 (m, 1H), 2.87-2.72 (m, 3H), 2.49-2.47 (dd, J=2.7, 5.1 Hz, 1H), 1.93-1.79 ppm (m, 2H).

Sources & evidence

ORD record
ord-50b372c479f9465f9ab66d692c47d296
Source dataset
uspto-grants-2012_07
Patent number
US08217184B2

Reaction notes

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