Isobutylamine → HCID 74949038, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 3-hydroxy-6,8-decadienoate (9) (86.1 g, 0.43 mol) and isobutylamine (95.3 g, 1.3 mol) were put into a 500 ml capacity flask equipped with a stirrer, a thermometer and a reflux condenser, followed by heating to 90° C. and stirring for 24 hours. After recovering isobutylamine under a reduced pressure, and when heptane (700 ml) was added, followed by cooling to 0° C., a white solid was precipitated. This solid was filtered and dried under a reduced pressure to obtain N-isobutyl-3-hydroxy-6,8-decadienamide (10) (85.2 g, 0.35 mol, yield 82%).

Provenance & Evidence