Cesium carbonate → HCID 57859960, compound

Participants

Reaction Steps

In the same manner as in Reference Example 150, ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,3,3-tetrafluoropropoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (460 mg, 93%) was obtained as a gray powder from the compound of Reference Example 40 (382 mg, 1.00 mmol), 2,2,3,3-tetrafluoropropyl trifluoromethanesulfonate (913 mg, 3.46 mmol), cesium carbonate (391 mg, 1.20 mmol) and DMF (10 mL). The title compound (310 mg, 95%) was obtained as a gray powder from the thus-obtained ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,3,3-tetrafluoropropoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (348 mg, 0.70 mmol) by a method similar to that in Reference Example 59.

Provenance & Evidence