1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester → 1-(2-Methoxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester

HRID 1513692Notes

Reaction equation

HRID 1513692 reaction equation
[CH2:1]([N:3]1[CH:7]=[C:6]([B:8]2[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]2)[CH:5]=[N:4]1)[CH3:2].[CH3:17][O:18]CCN1C=C(Br)C=N1>>[CH3:17][O:18][CH2:2][CH2:1][N:3]1[CH:7]=[C:6]([B:8]2[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:15])([CH3:16])[O:9]2)[CH:5]=[N:4]1

Participants

3

Reactant 2

HCID 113790451-Ethyl-1H-pyrazole-4-boronic acid, pinacol esterHCID 232478554-Bromo-1-(2-methoxyethyl)-1H-pyrazole

Product 1

HCID 112304911-(2-Methoxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester

Procedure

The title compound was prepared in the same manner as 1-ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, using 1-(2-methoxyethyl)-4-bromo-1H-pyrazole (see Ivachtchenko, A. V., et al J. Het. Chem. 2004, 41, 931-939).

Sources & evidence

ORD record
ord-035dc8cc84cd4342bdbdf653a0c4dee6
Source dataset
uspto-grants-2012_07
Patent number
US08217177B2

Reaction notes

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