Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Bromo-5-methoxypyridine | HCID 817163 | — |
| Catalyst | Copper Sulfate | HCID 24462 | — |
| Product | 5-Methoxypyridin-3-ylamine | HCID 12703595 | — |
Reaction Steps
3-Bromo-5-methoxypyridine (15 g) was added to a pressure vessel, and CuSO4 (3.9 g) and 25% aq. ammonia (150 mL) were added. The reaction mixture was stirred for 4 h at 135° C., then cooled to RT, basified with aqueous NaOH solution, and extracted with CH2Cl2. After evaporation of volatiles, 3-amino-5-methoxypyridine was obtained as yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08217177B2 |
|---|
| Source dataset | uspto-grants-2012_07 |
|---|
| ORD ID | ord-bae1a218774e477384329eb82fe1d6a9 |
|---|
| Source note | uspto-grants-2012_07 |
|---|
