1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester → 1-(Tetrahydrofuran-3-YL)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-1H-pyrazole

HRID 1513818Notes

Reaction equation

HRID 1513818 reaction equation
[CH2:1]([N:3]1[CH:7]=[C:6]([B:8]2[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]2)[CH:5]=[N:4]1)[CH3:2].BrC1C=NN([CH:23]2CC[O:25][CH2:24]2)C=1>>[O:25]1[CH2:24][CH2:23][CH:1]([N:3]2[CH:7]=[C:6]([B:8]3[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:15])([CH3:16])[O:9]3)[CH:5]=[N:4]2)[CH2:2]1

Participants

3

Reactant 2

HCID 113790451-Ethyl-1H-pyrazole-4-boronic acid, pinacol esterHCID 592316834-bromo-1-(oxolan-3-yl)-1H-pyrazole

Product 1

HCID 592317121-(Tetrahydrofuran-3-YL)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-1H-pyrazole

Procedure

The title compound was prepared in the same manner as 1-ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole starting with 4-bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole.

Sources & evidence

ORD record
ord-06ca56db5b2e4e169e92a484d67ef3db
Source dataset
uspto-grants-2012_07
Patent number
US08217177B2

Reaction notes

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