HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → 2,2-Difluoro-2-(quinolin-6-yl)acetohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | Methyl 2,2-difluoro-2-(quinolin-6-yl)acetate | HCID 58955252 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2,2-Difluoro-2-(quinolin-6-yl)acetohydrazide | HCID 58955250 | — |
Reaction Steps
A solution methyl 2,2-difluoro-2-(quinolin-6-yl)acetate (400 mg, 1686 μmol) and anhydrous hydrazine (2153 μl, 67453 μmol) in MeOH (4 mL) was stirred for 1 h at 23° C. The solvents were then removed under reduced pressure to provide product as a white solid. MS (ESI pos. ion) m/z: 238 (MH+). Calc'd exact mass for C11H9F2N3O: 237.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217177B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-f995d4424f5540eaa24421c4d36c29dd |
| Source note | uspto-grants-2012_07 |