HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1513865Generated: November 2, 2026
Ethyl Acetate → 6-Benzyloxy-2-(4-fluoro-phenyl)-naphthalen-1-ol
https://huagongshe.com/reaction/1513865
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methanesulfonic acid 6-benzyloxy-2-(4-fluoro-phenyl)-naphthalen-1-yl ester | HCID 86626527 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Benzyloxy-2-(4-fluoro-phenyl)-naphthalen-1-ol | HCID 67004754 | 89% |
Reaction Steps
Dissolve methanesulfonic acid 6-benzyloxy-2-(4-fluoro-phenyl)-naphthalen-1-yl ester (5.2 g, 12.3 mmol) in 5M sodium hydroxide (12 mL, 60 mmol), THF (86 mL) and MeOH (86 mL). Heat to 50° C. for 1 hour. Cool and add ethyl acetate (100 mL). Wash the organic layer with 1N HCl, saturated sodium bicarbonate solution and brine. Dry with magnesium sulfate and concentrate in vacuo to obtain 3.4 g (89%) of 6-benzyloxy-2-(4-fluoro-phenyl)-naphthalen-1-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08217032B2 |
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| Source dataset | uspto-grants-2012_07 |
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| ORD ID | ord-9dec469626de4aaa8d2d7ef49b30542a |
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| Source note | uspto-grants-2012_07 |
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