2-(hexamethyleneimino)ethyl chloride HCl → 1-(2-{4-[2-(3-Fluoro-phenyl)-6-methoxy-naphthalen-1-yloxy]phenoxy}-ethyl)-azepane hydrochloride

Participants

Reaction Steps

Prepare this compound following the procedure to make 1-(2-{4-[2-(3-fluoro-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine above, using 2-(hexamethyleneimino)-ethyl chloride hydrochloride to get a 100% yield of the free base of the title compound after radial chromatography. Form the hydrochloride salt by adding 0.8 mL of a 1 M HCl in Et2O solution: mass spectrum (ion spray) m/z=4.86 (M−Cl).

Provenance & Evidence