6-(3-Fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol hydrochloride → 5-[4-(2-Azepan-1-yl-ethoxy)-phenoxy]-6-(3-fluoro-phenyl)-naphthalen-2-ol hydrochloride

Participants

Reaction Steps

Prepare this compound following the procedure to make 6-(3-fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol hydrochloride above starting with 1-(2-{-4-[2-(3-fluoro-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-azepane hydrochloride, to get a 52% yield of the free of the title compound after radial chromatography. Form the hydrochloride salt by adding 0.8 mL of a 1 M HCl in Et2O solution: mass spectrum (ion spray) m/z=472 (M−Cl).

Provenance & Evidence